Pharmacokinetics made easy 9: Non-linear pharmacokinetics

Evidence for non-linear pharmacokinetics of oxytocin in anesthetizetized rat.

PURPOSE Because oxytocin (OT) is potentially useful in cardiovascular therapy but has hormonal roles on the cardiovascular and renal systems, we characterized its pharmacokinetic (PK) properties as a function of dose. METHODS A single intravenous bolus of OT was given at doses of 200, 300, 500, 1000, 3000, 5000 and 10000 ng/kg to anesthetized male rats (n >= 4 per dose). Blood samples (6) wer...

Non-linear estimation is easy

Non-linear state estimation and some related topics, like parametric estimation, fault diagnosis, and perturbation attenuation, are tackled here via a new methodology in numerical differentiation. The corresponding basic system theoretic definitions and properties are presented within the framework of differential algebra, which permits to handle system variables and their derivatives of any or...

Small-Dimensional Linear Programming and Convex Hulls Made Easy

We present two randomized algorithms. One solves linear programs involving m constraints in d variables in expected time O(m). The other constructs convex hulls of n points in Nd, d > 3, in expected time O(nln/2l). In both bounds d is considered to be a constant. In the linear programming algorithm the dependence of the time bound on d is of the form d!. The main virtue of our results lies in t...

Atom Bomb Made Easy

Concurrent Programming Made Easy

The task of programming concurrent systems is substantially more difficult than the task of programming sequential systems with respect to both correctness and efficiency. In this paper we describe a constraint-based methodology for writing concurrent applications. A system is modeled as: (a) a set of processes containing a sequence of “markers” denoting the processes points of interest; and (b...